{"id":1441,"date":"2024-10-22T14:29:02","date_gmt":"2024-10-22T06:29:02","guid":{"rendered":"https:\/\/cabit.top\/?p=1441"},"modified":"2024-10-22T16:56:00","modified_gmt":"2024-10-22T08:56:00","slug":"50-of-what-how-exactly-are-ic50-and-ec50-defined","status":"publish","type":"post","link":"https:\/\/cabit.top\/?p=1441","title":{"rendered":"50% \u662f\u4ec0\u4e48\uff1fIC50 \u548c EC50 \u7a76\u7adf\u662f\u5982\u4f55\u5b9a\u4e49\u7684\uff1f"},"content":{"rendered":"\n<p><br>IC50 \u548c EC50 \u7684\u6982\u5ff5\u662f\u836f\u7406\u5b66\u7684\u57fa\u7840\u3002EC50 \u662f\u836f\u7269\u4ea7\u751f\u534a\u6700\u5927\u53cd\u5e94\u65f6\u7684\u6d53\u5ea6\u3002IC50 \u662f\u6291\u5236\u5242\u53cd\u5e94\uff08\u6216\u7ed3\u5408\uff09\u51cf\u5c11\u4e00\u534a\u65f6\u7684\u6d53\u5ea6\u3002<\/p>\n\n\n\n<p>\u770b\u8d77\u6765\u5f88\u7b80\u5355\u3002\u4f46\u662f\uff0c\u5f53\u60a8\u5b9e\u9645\u53bb\u62df\u5408\u6570\u636e\u4ee5\u786e\u5b9a\u8fd9\u4e9b\u503c\u65f6\uff0c\u4f1a\u5b58\u5728\u4e00\u4e9b\u590d\u6742\u6027\u548c\u6b67\u4e49\u3002<\/p>\n\n\n\n<p>\u672c\u6587\u7684\u5176\u4f59\u90e8\u5206\u662f\u5173\u4e8e IC50\uff08I \u4ee3\u8868\u6291\u5236\uff0c\u4ee3\u8868\u5411\u4e0b\u503e\u659c\u7684\u5242\u91cf\u53cd\u5e94\u66f2\u7ebf\uff09\u3002\u6240\u6709\u8fd9\u4e9b\u60f3\u6cd5\u90fd\u53ef\u4ee5\u5e94\u7528\u4e8e\u523a\u6fc0\u66f2\u7ebf\u548c EC50\uff08E \u4ee3\u8868\u6709\u6548\uff09\u3002\u5f53\u4f60\u770b\u8fd9\u4e9b\u56fe\u65f6\uff0c\u53ea\u9700\u5012\u7acb\u5373\u53ef\u3002<\/p>\n\n\n\n<p><strong>\u7406\u60f3\u7684\u60c5\u51b5<\/strong><\/p>\n\n\n\n<p>\u6b64\u56fe\u663e\u793a\u4e86\u4e00\u79cd\u7406\u60f3\u60c5\u51b5\uff1a<\/p>\n\n\n\n<figure class=\"wp-block-image\"><img decoding=\"async\" src=\"https:\/\/cdn.graphpad.com\/faq\/1356\/images\/1356a.png\" alt=\"\"\/><\/figure>\n\n\n\n<p>\u7eff\u8272\u7b26\u53f7\u8868\u793a\u4f7f\u7528\u5bf9\u7167\u8fdb\u884c\u7684\u6d4b\u91cf\u3002\u5de6\u4fa7\u7684\u7b26\u53f7\uff08\u7a7a\u767d\uff09\u6ca1\u6709\u6291\u5236\u5242\uff0c\u56e0\u6b64\u5b9a\u4e49\u4e3a\u201c100%\u201d\u3002\u53f3\u4fa7\u7684\u7b26\u53f7\u5b58\u5728\u6700\u5927\u6d53\u5ea6\u7684\u6807\u51c6\u6291\u5236\u5242\uff0c\u56e0\u6b64\u5b9a\u4e49\u4e3a\u201c0%\u201d\u3002\u5b9e\u9a8c\u5242\u91cf\u53cd\u5e94\u66f2\u7ebf\u7684\u6570\u636e\uff08\u7ea2\u70b9\uff09\u4e00\u76f4\u5ef6\u4f38\u5230\u4e24\u4e2a\u5bf9\u7167\u503c\u4e4b\u95f4\u3002<\/p>\n\n\n\n<p>\u62df\u5408\u6b64\u66f2\u7ebf\u65f6\uff0c\u60a8\u9700\u8981\u51b3\u5b9a\u5982\u4f55\u62df\u5408\u66f2\u7ebf\u7684\u9876\u90e8\u5e73\u53f0\u3002\u60a8\u6709\u4e09\u79cd\u9009\u62e9\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u4ec5\u62df\u5408\u6570\u636e\uff0c\u5ffd\u7565<em>\u7a7a\u767d<\/em>\u5bf9\u7167\u503c\u3002<\/li>\n\n\n\n<li><em>\u5bf9\u7a7a\u767d<\/em>\u5bf9\u7167\u503c\u53d6\u5e73\u5747\u503c\uff0c\u5e76\u5c06\u53c2\u6570<em>Top<\/em>\u8bbe\u7f6e\u4e3a\u7b49\u4e8e\u7a7a\u767d\u5e73\u5747\u503c\u7684\u5e38\u6570\u503c\u3002<\/li>\n\n\n\n<li>\u8f93\u5165\u7a7a\u767d\u503c\uff0c\u5c31\u597d\u50cf\u5b83\u4eec\u662f\u5242\u91cf\u53cd\u5e94\u66f2\u7ebf\u7684\u4e00\u90e8\u5206\u4e00\u6837\u3002\u53ea\u9700\u8f93\u5165\u4e00\u4e2a\u4f4e\u5242\u91cf\uff0c\u53ef\u80fd\u662f 10\u00a0<sup>-10<\/sup>\u6216 10\u00a0<sup>-11<\/sup>\u3002\u60a8\u4e0d\u80fd\u8f93\u5165\u96f6\u200b\u200b\uff0c\u56e0\u4e3a\u96f6\u5728\u5bf9\u6570\u523b\u5ea6\u4e0a\u6ca1\u6709\u5b9a\u4e49\u3002<\/li>\n<\/ul>\n\n\n\n<p>\u8fd9\u4e9b\u65b9\u6cd5\u4e2d\u7684\u4efb\u4f55\u4e00\u79cd\u7684\u7ed3\u679c\u90fd\u5c06\u975e\u5e38\u76f8\u4f3c\uff0c\u56e0\u4e3a\u6570\u636e\u5f62\u6210\u5b8c\u6574\u7684\u5242\u91cf &#8211; \u53cd\u5e94\u66f2\u7ebf\uff0c\u5177\u6709\u6e05\u6670\u7684\u9876\u90e8\u5e73\u53f0\uff0c\u4e0e\u7a7a\u767d\u65e0\u6cd5\u533a\u5206\u3002\u6211\u66f4\u559c\u6b22\u7b2c\u4e09\u79cd\u65b9\u6cd5\uff0c\u56e0\u4e3a\u5b83\u5206\u6790\u4e86\u6240\u6709\u6570\u636e\uff0c\u4f46\u8fd9\u5e76\u4e0d\u662f\u4e00\u4e2a\u5f3a\u70c8\u7684\u504f\u597d\u3002<\/p>\n\n\n\n<p>\u540c\u6837\uff0c\u6709\u4e09\u79cd\u65b9\u6cd5\u53ef\u4ee5\u5904\u7406\u5e95\u90e8\u5e73\u53f0\uff1a\u4ec5\u62df\u5408\u6570\u636e\uff0c\u5c06 Bottom \u8bbe\u7f6e\u4e3a\u7b49\u4e8e NS \u5bf9\u7167\u5e73\u5747\u503c\u7684\u5e38\u6570\uff0c\u5e76\u5c06 NS \u5bf9\u7167\u653e\u5165\u62df\u5408\u4e2d\uff0c\u5c31\u597d\u50cf\u5b83\u4eec\u662f\u975e\u5e38\u9ad8\u6d53\u5ea6\u7684\u6291\u5236\u5242\u4e00\u6837\u3002<\/p>\n\n\n\n<p>\u8fd9\u662f\u7406\u60f3\u7684\u60c5\u51b5\u3002IC50 \u7684\u542b\u4e49\u6ca1\u6709\u6b67\u4e49\u3002<\/p>\n\n\n\n<p><strong>IC50 \u53ef\u4ee5\u7528\u4e24\u79cd\u65b9\u5f0f\u5b9a\u4e49\u7684\u60c5\u51b5<\/strong><\/p>\n\n\n\n<p>\u8be5\u56fe\u663e\u793a\u4e86\u4e00\u79cd\u4e0d\u5bfb\u5e38\u7684\u60c5\u51b5\uff0c\u5373\u6291\u5236\u66f2\u7ebf\u7a33\u5b9a\u5728\u8fdc\u9ad8\u4e8e\u9ad8\u6d53\u5ea6\u6807\u51c6\u836f\u7269\u5b9a\u4e49\u7684\u5bf9\u7167\u503c \uff08NS\uff09 \u4e4b\u4e0a\u3002\u8fd9\u5bfc\u81f4\u4e86 IC50 \u7684\u66ff\u4ee3\u5b9a\u4e49\u3002<\/p>\n\n\n\n<figure class=\"wp-block-image\"><img decoding=\"async\" src=\"https:\/\/cdn.graphpad.com\/faq\/1356\/images\/1356b.png\" alt=\"\"\/><\/figure>\n\n\n\n<p>\u663e\u7136\uff0c\u5355\u4e2a\u503c\u65e0\u6cd5\u6982\u62ec\u8fd9\u6837\u7684\u66f2\u7ebf\u3002\u60a8\u81f3\u5c11\u9700\u8981\u4e24\u4e2a\u503c\uff0c\u4e00\u4e2a\u7528\u4e8e\u91cf\u5316\u66f2\u7ebf\u7684\u4e2d\u95f4\u503c\uff08\u836f\u7269\u7684\u6548\u529b\uff09\uff0c\u53e6\u4e00\u4e2a\u7528\u4e8e\u91cf\u5316\u66f2\u7ebf\u7684\u4f4e\u5ea6\uff08\u836f\u7269\u7684\u6700\u5927\u6548\u679c\uff09\u3002<\/p>\n\n\n\n<p>\u4e0a\u56fe\u663e\u793a\u4e86 IC50 \u7684\u4e24\u4e2a\u5b9a\u4e49\u3002<\/p>\n\n\n\n<p><strong>\u76f8\u5bf9 IC50<\/strong>&nbsp;\u662f\u8fc4\u4eca\u4e3a\u6b62\u6700\u5e38\u89c1\u7684\u5b9a\u4e49\uff0c\u901a\u5e38\u7701\u7565\u5f62\u5bb9\u8bcd<em>\u76f8\u5bf9<\/em>\u3002\u5b83\u662f\u4f7f\u66f2\u7ebf\u4e0b\u964d\u5230\u66f2\u7ebf\u9876\u90e8\u548c\u5e95\u90e8\u5e73\u53f0\u4e4b\u95f4\u7684\u4e2d\u95f4\u70b9\u6240\u9700\u7684\u6d53\u5ea6\u3002\u5728 IC50 \u7684\u8fd9\u4e2a\u5b9a\u4e49\u4e2d\uff0cNS \u503c\u5b8c\u5168\u88ab\u5ffd\u7565\u4e86\u3002\u8be5\u5b9a\u4e49\u662f\u6fc0\u52a8\u5242\u548c\u62ee\u6297\u5242\u76f8\u4e92\u4f5c\u7528\u7684\u7ecf\u5178\u836f\u7406\u5b66\u5206\u6790\u7684\u57fa\u7840\u3002\u5728\u9002\u5f53\u8003\u8651\u751f\u7269\u7cfb\u7edf\u548c\u76f8\u4e92\u4f5c\u7528\u914d\u4f53\u7684\u6d53\u5ea6\u7684\u60c5\u51b5\u4e0b\uff0c\u4f30\u8ba1\u7684 Kd \u503c\u901a\u5e38\u53ef\u4ee5\u4ece\u4ee5\u8fd9\u79cd\u65b9\u5f0f\u5b9a\u4e49\u7684 IC50 \u503c\u5f97\u51fa\uff08\u5bf9\u4e8e\u4e0b\u9762\u63d0\u5230\u7684\u201c\u6240\u8c13\u7684\u7edd\u5bf9 IC50\u201d\uff0c\u60c5\u51b5\u5e76\u975e\u5982\u6b64\uff09\u3002<\/p>\n\n\n\n<p>\u5728\u7a7a\u767d\u503c\u548c NS \u503c\u4e4b\u95f4\u5f15\u53d1\u54cd\u5e94\u7684\u6d53\u5ea6<a href=\"http:\/\/www.ncgc.nih.gov\/guidance\/section3.html\" target=\"_blank\" rel=\"noreferrer noopener\">\u6709\u65f6\u79f0\u4e3a<\/a><strong>\u7edd\u5bf9 IC50<\/strong>\uff0c\u6c34\u5e73\u865a\u7ebf\u8868\u793a\u5982\u4f55\u5b9a\u4e49 100% \u548c 0%\uff0c\u7136\u540e\u5b9a\u4e49 50%\u3002\u8fd9\u4e2a\u672f\u8bed\u5e76\u4e0d\u5b8c\u5168\u6807\u51c6\u3002\u7531\u4e8e\u8be5\u503c\u4e0d\u80fd\u91cf\u5316\u836f\u7269\u7684\u6548\u529b\uff0c\u56e0\u6b64\u56fd\u9645\u836f\u7406\u5b66\u8054\u5408\u4f1a\u53d7\u4f53\u547d\u540d\u59d4\u5458\u4f1a \uff081\uff09 \u7684\u4f5c\u8005\u8ba4\u4e3a\u7edd\u5bf9 IC50 \uff08\u548c\u8be5\u672f\u8bed\uff09 \u7684\u6982\u5ff5\u6ca1\u6709\u7528 \uff08R. Neubig\uff0c\u4e2a\u4eba\u901a\u4fe1\uff09\u3002\u6211\u540c\u610f\u3002<\/p>\n\n\n\n<p>\u8be5\u6982\u5ff5\uff08\u4f46\u4e0d\u662f\u672f\u8bed\u201c\u7edd\u5bf9 IC50\u201d\uff09\u7528\u4e8e\u91cf\u5316\u51cf\u7f13\u7ec6\u80de\u751f\u957f\u7684\u836f\u7269\u3002<a href=\"http:\/\/dtp.nci.nih.gov\/docs\/compare\/compare_methodology.html\" target=\"_blank\" rel=\"noreferrer noopener\">\u7f29\u5199 GI50 \u7528\u4e8e<\/a>\u6211\u4eec\u8fd9\u91cc\u6240\u8bf4\u7684\u7edd\u5bf9 IC50\u3002\u73af\u5883\u4fdd\u62a4\u7f72 \uff08EPA\uff09 \u4e5f\u4f7f\u7528\u5b83\u6765\u8bc4\u4f30<a href=\"http:\/\/www.regulations.gov\/search\/Regs\/contentStreamer?objectId=0900006480a41cf7&amp;disposition=attachment&amp;contentType=pdf\" target=\"_blank\" rel=\"noreferrer noopener\">\u5185\u5206\u6ccc\u5e72\u6270\u7269<\/a>\uff08\u9644\u5f55 A\uff09\u3002\u4ed6\u4eec\u4f7f\u7528\u672f\u8bed IC50 \u6765\u6307\u4ee3\u7edd\u5bf9 IC50\uff0c\u4f7f\u7528\u672f\u8bed EC50 \u6765\u6307\u4ee3\u76f8\u5bf9 IC50\u3002\u4ed6\u4eec\u4e0d\u4f7f\u7528\u672f\u8bed\u00a0<em>relative<\/em>\u00a0\u548c\u00a0<em>absolute<\/em>\u3002<\/p>\n\n\n\n<p>\u5982\u679c\u60a8\u771f\u7684\u60f3\u4f7f\u7528\u7edd\u5bf9 IC50\uff0c\u4ee5\u4e0b\u662f\u62df\u5408\u66f2\u7ebf\u4ee5\u627e\u5230\u5b83<a href=\"http:\/\/www.graphpad.com\/support\/faqid\/1566\/\" target=\"_blank\" rel=\"noreferrer noopener\">\u7684\u8bf4\u660e<\/a>\u3002<\/p>\n\n\n\n<p><strong><a><\/a>\u5242\u91cf-\u53cd\u5e94\u66f2\u7ebf\u4e0d\u5b8c\u6574<\/strong><\/p>\n\n\n\n<figure class=\"wp-block-image\"><img decoding=\"async\" src=\"https:\/\/cdn.graphpad.com\/faq\/1356\/images\/1356c.png\" alt=\"\"\/><\/figure>\n\n\n\n<p>\u4efb\u4f55\u901a\u8fc7\u5bf9\u4e0a\u56fe\u4e2d\u7684\u6570\u636e\u62df\u5408\u66f2\u7ebf\u6765\u786e\u5b9a IC50 \u7684\u5c1d\u8bd5\u90fd\u662f\u65e0\u7528\u7684\u3002\u66f2\u7ebf\u62df\u5408\u7a0b\u5e8f\u53ef\u80fd\u80fd\u591f\u5c06\u5242\u91cf-\u53cd\u5e94\u66f2\u7ebf\u62df\u5408\u5230\u6570\u636e\uff0c\u4e5f\u53ef\u80fd\u4e0d\u80fd\u3002\u4f46\u5982\u679c\u66f2\u7ebf\u62df\u5408\uff0c\u5219 IC50 \u7684\u503c\u53ef\u80fd\u6beb\u65e0\u610f\u4e49\uff0c\u5e76\u4e14\u5177\u6709\u975e\u5e38\u5bbd\u7684\u7f6e\u4fe1\u533a\u95f4\u3002\u6570\u636e\u6839\u672c\u4e0d\u4f1a\u5f62\u6210\u9876\u90e8\u5e73\u53f0\uff08\u5b9a\u4e49 100\uff09\u6216\u5e95\u90e8\u5e73\u53f0\uff08\u5b9a\u4e49 0\uff09\u3002\u5982\u679c\u6570\u636e\u6ca1\u6709\u5b9a\u4e49 100 \u6216 0\uff0c\u90a3\u4e48 50 \u4e5f\u662f\u672a\u5b9a\u4e49\u7684\uff0cIC50 \u4e5f\u662f\u5982\u6b64\u3002<\/p>\n\n\n\n<p>\u5982\u679c\u60a8\u8fd8\u5177\u6709\u5b9a\u4e49 100 \u548c 0 \u7684\u63a7\u5236\u503c\uff0c\u5219\u53ef\u4ee5\u8f7b\u677e\u62df\u5408\u66f2\u7ebf\u3002\u4e0b\u9762\u7684\u66f2\u7ebf\u662f\u901a\u8fc7\u62df\u5408\u5242\u91cf\u53cd\u5e94\u66f2\u7ebf\u521b\u5efa\u7684\uff0c\u4f46\u5c06 Top \u5e73\u53f0\u9650\u5236\u4e3a\u7b49\u4e8e Blanks \u503c\u7684\u5e73\u5747\u503c\u7684\u5e38\u6570\u503c\uff0c\u4ee5\u53ca Bottom \u5e73\u53f0\u7b49\u4e8e NS \u503c\u7684\u5e73\u5747\u503c\u3002<\/p>\n\n\n\n<figure class=\"wp-block-image\"><img decoding=\"async\" src=\"https:\/\/cdn.graphpad.com\/faq\/1356\/images\/1356d2.png\" alt=\"\"\/><\/figure>\n\n\n\n<p>\u53ea\u6709\u5f53\u60a8\u5047\u8bbe\u8f83\u9ad8\u6d53\u5ea6\u7684\u6291\u5236\u5242\u6700\u7ec8\u4f1a\u6291\u5236\u81f3 NS \u503c\u65f6\uff0c\u4ee5\u8fd9\u79cd\u65b9\u5f0f\u62df\u5408\u7684 IC50 \u503c\u624d\u6709\u610f\u4e49\u3002\u8fd9\u662f\u4e00\u4e2a\u65e0\u6cd5\u7528\u624b\u5934\u6570\u636e\u68c0\u9a8c\u7684\u5047\u8bbe\u3002<\/p>\n\n\n\n<p>\u76f8\u5bf9 IC50 \u548c\u7edd\u5bf9 IC50 \u4e4b\u95f4\u7684\u533a\u522b\u5e76\u4e0d\u771f\u6b63\u9002\u7528\u4e8e\u8fd9\u4e9b\u6570\u636e\u3002\u7531\u4e8e\u6570\u636e\u672a\u5b9a\u4e49\u5e95\u90e8\u5e73\u53f0\uff0c\u56e0\u6b64\u5fc5\u987b\u76f8\u5bf9\u4e8e NS \u5bf9\u7167\u503c\u5b9a\u4e49 IC50\u3002<\/p>\n\n\n\n<p><strong>\u62df\u5408\u5f52\u4e00\u5316\u6570\u636e<\/strong><\/p>\n\n\n\n<p>\u4ece\u4e0a\u9762\u7684\u6240\u6709\u793a\u4f8b\u4e2d\u53ef\u4ee5\u770b\u51fa\uff0c\u6ca1\u6709\u5fc5\u8981\u5c06\u6570\u636e\u6807\u51c6\u5316\u4ee5\u4ece 100% \u4e0b\u964d\u5230 0%\u3002\u60a8\u53ef\u4ee5\u4f7f\u7528\u81ea\u7136\u5355\u4f4d\u7684\u6570\u636e\u62df\u5408\u66f2\u7ebf\u3002\u4e00\u4e2a\u5e38\u89c1\u7684\u9519\u8bef\u662f\u5047\u8bbe\u62df\u5408\u5242\u91cf-\u53cd\u5e94\u66f2\u7ebf\u9700\u8981\u9996\u5148\u5bf9\u6570\u636e\u8fdb\u884c\u5f52\u4e00\u5316\u3002<\/p>\n\n\n\n<p>\u5982\u679c\u60a8\u9009\u62e9\u5bf9\u6570\u636e\u8fdb\u884c\u5f52\u4e00\u5316\uff0c\u5219\u5fc5\u987b\u4ed4\u7ec6\u8003\u8651\uff08\u5e76\u5728\u8bba\u6587\u7684\u65b9\u6cd5\u90e8\u5206\u8bb0\u5f55\uff09\u5982\u4f55\u5b9a\u4e49 100% \u548c 0%\u3002\u60a8\u53ef\u4ee5\u4f7f\u7528\u4e09\u79cd\u7b56\u7565\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u4ece\u5916\u90e8\u63a7\u4ef6\uff08\u4e0a\u56fe\u4e2d\u7684 Blank \u548c NS\uff09\u3002\u7531\u4e8e\u8fd9\u4e9b\u503c\u975e\u5e38\u91cd\u8981\uff0c\u56e0\u6b64\u8bf7\u8003\u8651\u4f7f\u7528\u6bd4\u7528\u4e8e\u5b9e\u9a8c\u5176\u4f59\u90e8\u5206\u66f4\u591a\u7684\u91cd\u590d\u6765\u6d4b\u91cf\u8fd9\u4e9b\u5bf9\u7167\u3002<\/li>\n\n\n\n<li>\u6765\u81ea\u6781\u4f4e\u548c\u975e\u5e38\u9ad8\u6d53\u5ea6\u7684\u4f9b\u8bd5\u7269\u8d28\u3002<\/li>\n\n\n\n<li>\u6765\u81ea\u975e\u7ebf\u6027\u56de\u5f52\u7684\u9ad8\u539f\u3002\u9996\u5148\u62df\u5408\u66f2\u7ebf\uff0c\u7136\u540e\u4f7f\u7528 Top \u548c Bottom \u5e73\u53f0\u7684\u6700\u4f73\u62df\u5408\u503c\u5bf9\u6570\u636e\u8fdb\u884c\u5f52\u4e00\u5316\u3002<\/li>\n<\/ul>\n\n\n\n<p>\u5982\u679c\u60a8\u62df\u5408\u6807\u51c6\u5316\u6570\u636e\uff0c\u60a8\u53ef\u80fd\u5e0c\u671b Prism \u5f3a\u5236\u66f2\u7ebf\u4ece 100 \u4e0b\u964d\u5230 0\u3002\u9664\u975e\u4f60\u544a\u8bc9\u5b83\uff0c\u5426\u5219\u5b83\u4e0d\u4f1a\u77e5\u9053\u8fd9\u6837\u505a\u3002\u4e0d\u8981\u72af\u4e00\u4e9b\u5e38\u89c1\u7684\u9519\u8bef\uff0c\u5373\u5bf9\u6570\u636e\u8fdb\u884c\u5f52\u4e00\u5316\uff0c\u4f46\u4e0d\u5c06\u66f2\u7ebf\u4ece 100 \u9650\u5236\u5230 0\u3002\u60a8\u53ef\u4ee5\u901a\u8fc7\u4e24\u79cd\u65b9\u5f0f\u7ea6\u675f\u66f2\u7ebf\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u9009\u62e9\u9002\u5e94\u89c4\u8303\u5316\u6a21\u578b\u3002Prism \u4e2d\u5185\u7f6e\u7684\u5f52\u4e00\u5316\u6a21\u578b\u59cb\u7ec8\u4ecb\u4e8e 0 \u548c 100 \u4e4b\u95f4\u3002<\/li>\n\n\n\n<li>\u4f7f\u7528\u66f4\u901a\u7528\u7684\u6a21\u578b\uff0c\u8f6c\u5230 Constrain \u9009\u9879\u5361\uff0c\u5e76\u5c06 Bottom \u8bbe\u7f6e\u4e3a\u5e38\u91cf\u503c 0.0\uff0c\u5c06 Top \u8bbe\u7f6e\u4e3a\u5e38\u91cf\u503c 100.0\u3002<\/li>\n<\/ul>\n\n\n\n<p><strong>\u603b\u7ed3<\/strong><\/p>\n\n\n\n<p>IC50\uff08\u6216 EC50\uff09\u7684\u6982\u5ff5\u6709\u70b9\u6a21\u68f1\u4e24\u53ef\uff0c\u9664\u975e\u60a8\u660e\u786e\u6307\u5b9a\u54ea\u4e9b\u503c\u5b9a\u4e49 100% \u548c 0%\u3002<\/p>\n\n\n\n<p><strong>\u53c2\u8003<\/strong><\/p>\n\n\n\n<p>1. R. R. Neubig et al.\u00a0<a href=\"http:\/\/www.iuphar-db.org\/termsAndSymbols.pdf\" target=\"_blank\" rel=\"noreferrer noopener\">\u56fd\u9645\u836f\u7406\u5b66\u8054\u5408\u4f1a\u53d7\u4f53\u547d\u540d\u548c\u836f\u7269\u5206\u7c7b\u59d4\u5458\u4f1a\u3002XXXVIII. \u5b9a\u91cf\u836f\u7406\u5b66\u672f\u8bed\u548c\u7b26\u53f7\u7684\u66f4\u65b0<\/a>\u3002Pharmacol Rev \uff082003\uff09\uff0c\u7b2c 55 \u5377\u7b2c 4 \u671f\uff0c\u7b2c 597-606 \u9875<\/p>\n\n\n\n<p><strong>\u4e0b\u8f7d<\/strong><\/p>\n\n\n\n<p><a href=\"http:\/\/cdn.graphpad.com\/faq\/1356\/file\/1356.pzf\" target=\"_blank\" rel=\"noreferrer noopener\">\u4e0b\u8f7d\u7528\u4e8e\u521b\u5efa\u672c\u6587\u4e2d\u6240\u6709\u56fe\u5f62\u7684 Prism \u6587\u4ef6\u3002<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>IC50 \u548c EC50 \u7684\u6982\u5ff5\u662f&#46;&#46;&#46;<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[18],"tags":[],"class_list":["post-1441","post","type-post","status-publish","format-standard","hentry","category-graphpad-prism"],"_links":{"self":[{"href":"https:\/\/cabit.top\/index.php?rest_route=\/wp\/v2\/posts\/1441","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cabit.top\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cabit.top\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cabit.top\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/cabit.top\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=1441"}],"version-history":[{"count":12,"href":"https:\/\/cabit.top\/index.php?rest_route=\/wp\/v2\/posts\/1441\/revisions"}],"predecessor-version":[{"id":1453,"href":"https:\/\/cabit.top\/index.php?rest_route=\/wp\/v2\/posts\/1441\/revisions\/1453"}],"wp:attachment":[{"href":"https:\/\/cabit.top\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=1441"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cabit.top\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=1441"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cabit.top\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=1441"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}