{"id":123,"date":"2021-11-28T12:17:40","date_gmt":"2021-11-28T04:17:40","guid":{"rendered":"http:\/\/cabit.top\/?p=123"},"modified":"2023-08-04T12:14:13","modified_gmt":"2023-08-04T04:14:13","slug":"%e5%89%82%e9%87%8f-%e5%8f%8d%e5%ba%94%e6%9b%b2%e7%ba%bf%e4%bb%8b%e7%bb%8d","status":"publish","type":"post","link":"https:\/\/cabit.top\/?p=123","title":{"rendered":"\u5242\u91cf-\u53cd\u5e94\u66f2\u7ebf\u4ecb\u7ecd"},"content":{"rendered":"<p><strong>\u5242\u91cf-\u53cd\u5e94\u66f2\u7ebf\u4ecb\u7ecd<\/strong><\/p>\n<p><strong>\u4ec0\u4e48\u662f\u5242\u91cf-\u53cd\u5e94\u66f2\u7ebf(dose-response curve)\uff1f<\/strong><\/p>\n<p>\u5242\u91cf-\u53cd\u5e94\u66f2\u7ebf\u53ef\u7528\u6765\u7ed8\u5236\u591a\u79cd\u5b9e\u9a8c\u7684\u7ed3\u679c\u3002 X\u8f74\u753b\u51fa\u836f\u7269\u6216\u6fc0\u7d20\u7684\u6d53\u5ea6\u3002 Y\u8f74\u753b\u51fa\u7684\u53cd\u5e94(response)\uff0c\u8fd9\u51e0\u4e4e\u53ef\u4ee5\u662f\u4efb\u4f55\u7684\u5185\u5bb9\u3002\u4f8b\u5982\uff0c\u54cd\u5e94\u53ef\u80fd\u662f\u9176\u7684\u6d3b\u6027\uff0c\u7ec6\u80de\u5185\u7b2c\u4e8c\u4fe1\u4f7f(second messenger)\u7684\u7d2f\u79ef\uff0c\u819c\u7535\u4f4d\uff0c\u5206\u6ccc\u7684\u4e00\u79cd\u6fc0\u7d20\uff0c\u5fc3\u810f\u7387\u6216\u808c\u8089\u7684\u6536\u7f29\u3002<\/p>\n<p>&#8220;\u5242\u91cf&#8221;\u4e00\u8bcd\u7ecf\u5e38\u88ab\u7528\u7684\u5f88\u8f7b\u7387\uff0c\u4e25\u683c\u7684&#8221;\u5242\u91cf&#8221;\u4e00\u8bcd\u53ea\u9002\u7528\u4e8e\u65bd\u7528\u5230\u52a8\u7269\u6216\u4eba\u8eab\u4e0a\u7684\u5b9e\u9a8c\uff0c\u5728\u8fd9\u91cc\u60a8\u7ba1\u7406\u4e0d\u540c\u5242\u91cf\u7684\u836f\u7269\u8fdb\u884c\u5b9e\u9a8c\uff0c\u5728\u8fd9\u60a8\u7ba1\u7406\u5404\u79cd\u7684\u836f\u7269\u5242\u91cf\u3002\u4f60\u4e0d\u77e5\u9053\u5b9e\u9645\u7684\u836f\u7269\u6d53\u5ea6 &#8211; \u60a8\u53ea\u77e5\u9053\u60a8\u7ba1\u7406\u7684\u5242\u91cf\u3002\u7136\u800c\uff0c&#8221;\u5242\u91cf &#8211; \u53cd\u5e94\u66f2\u7ebf&#8221;\u8fd9\u4e2a\u8bcd\u7684\u4e5f\u8f83\u4e3a\u8f7b\u7387\u7684\u7528\u6765\u5f62\u5bb9\u4f53\u5916\u5b9e\u9a8c(vitro experiments),\u5728\u8fd9\u60a8\u5e94\u7528\u5df2\u77e5\u6d53\u5ea6\u7684\u836f\u7269\u3002\u672f\u8bed\u201c\u6d53\u5ea6-\u53cd\u5e94\u66f2\u7ebf\u201d\u662f\u5bf9\u8fd9\u4e9b\u5b9e\u9a8c\u7684\u7ed3\u679c\u66f4\u7cbe\u786e\u7684\u6807\u7b7e\u3002\uff0c&#8221;\u5242\u91cf &#8211; \u53cd\u5e94\u66f2\u7ebf&#8221;\u5076\u5c14\u66f4\u8f7b\u7387\u7684\u7528\u6765\u6d89\u53ca\u60a8\u6539\u53d8\u4e00\u4e9b\u5176\u4ed6\u53d8\u91cf\u6c34\u5e73\uff0c\u6bd4\u5982\u6e29\u5ea6\u6216\u7535\u538b\uff0c\u7684\u5b9e\u9a8c\u3002<\/p>\n<p>\u6fc0\u52a8\u5242(agonist )\u662f\u4e00\u79cd\u4f1a\u5bfc\u81f4\u53cd\u5e94\u7684\u836f\u7269\u3002\u5982\u679c\u60a8\u7ba1\u7406\u4e0d\u540c\u6d53\u5ea6\u7684\u6fc0\u52a8\u5242\uff0c\u5242\u91cf\u53cd\u5e94\u66f2\u7ebf\u5c31\u4f1a\u50cf&#8221;\u4e0a\u5c71\u5761&#8221;,\u4ece\u5de6\u4fa7\uff08\u4f4e\u6d53\u5ea6\uff09\u5230\u53f3\u4fa7\uff08\u9ad8\u6d53\u5ea6)\u3002\u5b8c\u5168\u6fc0\u52a8\u5242(full agonist)\u662f\u4e00\u4e2a\u7684\u836f\u7269\uff0c\u4f3c\u4e4e\u80fd\u591f\u4ea7\u751f\u5b8c\u6574\u7684\u7ec4\u7ec7\u53cd\u5e94\u3002\u90e8\u5206\u6fc0\u52a8\u5242(partial agonist)\u662f\u4e00\u4e2a\u53ef\u4ee5\u5f15\u8d77\u53cd\u5e94\u7684\u836f\u7269\uff0c\u4f46\u662f\u5b83\u7684\u6700\u5927\u53cd\u5e94\u6bd4\u5b8c\u5168\u6fc0\u52a8\u5242\u7684\u6700\u5927\u53cd\u5e94\u8981\u5c0f\u3002\u62ee\u6297\u5242(antagonist )\u662f\u4e00\u79cd\u836f\u7269\uff0c\u5b83\u672c\u8eab\u4e0d\u4f1a\u5f15\u8d77\u53cd\u5e94\uff0c\u4f46\u4f1a\u963b\u6b62agonist-mediated\u53cd\u5e94\u3002\u5982\u679c\u60a8\u53d8\u5316\u62ee\u6297\u5242\u7684\u6d53\u5ea6(\u5bf9\u5e94\u4e00\u4e2a\u56fa\u5b9a\u7684\u6fc0\u52a8\u5242\u6d53\u5ea6)\uff0c\u5242\u91cf\u53cd\u5e94\u66f2\u7ebf\u5c06\u4e0b\u5761\u8fd0\u884c(run downhill)\u3002<\/p>\n<p><!--more--><\/p>\n<p><strong>\u5242\u91cf-\u53cd\u5e94\u66f2\u7ebf\u7684\u5f62\u72b6<\/strong><\/p>\n<p>\u5728\u7ed1\u5b9a\u6fc0\u52a8\u5242\u5230\u53d7\u4f53(receptor)\u5e76\u4ea7\u751f\u53cd\u5e94\u4e4b\u95f4\u6709\u5f88\u591a\u6b65\u9aa4\u3002\u56e0\u6b64\u6839\u636e\u60a8\u4f7f\u7528\u7684\u836f\u7269\u548c\u60a8\u6d4b\u91cf\u7684\u53cd\u5e94\uff0c\u5242\u91cf-\u53cd\u5e94\u66f2\u7ebf\u51e0\u4e4e\u53ef\u4ee5\u6709\u4efb\u4f55\u5f62\u72b6\u3002\u7136\u540e\uff0c\u5728\u5f88\u591a\u7cfb\u7edf\u4e2d\u7684\u5242\u91cf &#8211; \u53cd\u5e94\u66f2\u7ebf\u9075\u5faa\u4e00\u4e2a\u6807\u51c6\u7684\u5f62\u72b6\uff0c\u5982\u4e0b\u56fe\u6240\u793a<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.cabit.com.cn\/pic\/tech\/graphpad\/idr1\/2023be90.gif\" width=\"315\" height=\"233\" \/><\/p>\n<p>\u5242\u91cf-\u53cd\u5e94\u5b9e\u9a8c\u4e2d\u901a\u5e38\u4f7f\u752810-20\u6fc0\u52a8\u5242\uff0c\u5728\u5bf9\u6570\u523b\u5ea6(logarithmic scale)\u4e0a\u6709\u8fd1\u4f3c\u76f8\u7b49\u7684\u95f4\u9694\u3002\u4f8b\u5982\uff0c\u5242\u91cf\u53ef\u80fd\u662f1\uff0c3\uff0c10\uff0c30\uff0c100\uff0c300\uff0c1000\uff0c3000\u548c10000nM.\u5230\u5bf9\u6570\u65f6\uff0c\u8fd9\u4e9b\u503c\u6709\u540c\u6837\u7684\u95f4\u9694\uff1a0.0\uff0c0.5\uff0c1.0\uff0c1.5\uff0c2.0\uff0c2.5\uff0c3.0\uff0c3.5\u548c4.0\u3002<\/p>\n<p>\u6ce8\u610f\uff1a3\u7684\u5bf9\u6570\u5b9e\u9645\u4e0a\u662f0.4771\uff0c\u800c\u4e0d\u662f0.50\u3002 0.5\u7684\u53cd\u5bf9\u6570\u662f3.1623\u3002\u56e0\u6b64\uff0c\u4e3a\u4e86\u4f7f\u5242\u91cf\u5728\u5bf9\u6570\u5c3a\u5ea6\u4e0a\u80fd\u771f\u6b63\u7b49\u95f4\u9694\uff0c\u6d53\u5ea6\u5e94\u8be5\u662f1.0\uff0c3.1623\uff0c10.0\uff0c31.623\u7b49<\/p>\n<p>\u7531\u4e8e\u6fc0\u52a8\u5242\u7ea6\u675f\u529b\u548c\u53cd\u5e94\u4e4b\u95f4\u7684\u8054\u7cfb\u662f\u975e\u5e38\u590d\u6742\u7684\uff0c\u4efb\u4f55\u5f62\u72b6\u90fd\u662f\u53ef\u80fd\u7684\u3002\u8fd9\u4f3c\u4e4e\u5f88\u5947\u602a\uff0c\u56e0\u6b64\uff0c\u5982\u6b64\u591a\u7684\u5242\u91cf\u53cd\u5e94-\u66f2\u7ebf\u6709\u76f8\u540c\u7684\u53d7\u4f53\u7ed3\u5408\u66f2\u7ebf\u5f62\u72b6\u3002\u6700\u7b80\u5355\u7684\u89e3\u91ca\u662f\uff0c\u53d7\u4f53\u7ed3\u5408\u548c\u53cd\u5e94\u4e4b\u95f4\u7684\u8054\u7cfb\u662f\u76f4\u63a5\u7684\uff0c\u8fd9\u6837\u7684\u53cd\u5e94\u662f\u6210\u6b63\u6bd4\u7684\u53d7\u4f53\u7ed3\u5408\u3002\u7136\u800c\uff0c\u5728\u5927\u591a\u6570\u7cfb\u7edf\u4e2d\u7684\u4e00\u4e2a\u6216\u591a\u4e2a\u7b2c\u4e8c\u4fe1\u4f7f\u7cfb\u7edf(second-messenger systems)\u94fe\u63a5\u53d7\u4f53\u7ed3\u5408\u53cd\u5e94\u3002\u4f8b\u5982\uff0c\u7ed3\u5408\u6fc0\u52a8\u5242\u6fc0\u6d3b\u817a\u82f7\u9178\u73af\u5316\u9176\uff0c\u4ece\u800c\u4ea7\u751f\u7b2c\u4e8c\u4fe1\u4f7fcAMP\u3002\u7b2c\u4e8c\u4fe1\u4f7f\u53ef\u4ee5\u7ed1\u5b9a\u6548\u5e94\uff08\u5982\u86cb\u767d\u6fc0\u9176\u5e76\u542f\u52a8\u54cd\u5e94\u3002<\/p>\n<p>\u5982\u679c\u4e00\u4e2a\u7b2c\u4e8c\u4fe1\u4f7f\u4f20\u8fbe\u53cd\u5e94\u7684\u8bdd\uff0c\u60a8\u671f\u671b\u7684\u5242\u91cf-\u53cd\u5e94\u66f2\u7ebf\u770b\u8d77\u6765\u4f1a\u662f\u4ec0\u4e48\u6837\u5b50\u5462?\u5982\u679c\u60a8\u8ba4\u4e3a\u7b2c\u4e8c\u4fe1\u4f7f\u7684\u751f\u4ea7\u662f\u4e0e\u53d7\u4f53\u5360\u7528\u6210\u6b63\u6bd4\uff0c\u6fc0\u52a8\u5242\u6d53\u5ea6\u4e0e\u7b2c\u4e8c\u4fe1\u4f7f\u6d53\u5ea6\u56fe\u5c06\u4f1a\u548c\u53d7\u4f53\u5360\u7528\u6709\u76f8\u540c\u7684\u5f62\u72b6\uff08\u53cc\u66f2\u7ebf\uff0c\u5982\u679c\u7ed8\u5236\u5728\u4e00\u4e2a\u7ebf\u6027\u5c3a\u5ea6\u4e0a\uff0c\u5982\u679c\u7ed8\u5236\u6210\u534a\u5bf9\u6570\u56fe\u5f62\uff0c\u5219\u662f\u4e00\u4e2a\u659c\u7387\u56e0\u5b50\u4e3a1.0\u7684S\u578b\u66f2\u7ebf).\u5982\u679c\u7b2c\u4e8c\u4fe1\u4f7f\u7ed1\u5b9a\u5230\u4e00\u4e2a\u6548\u5e94\u5668(effector),\u7ed1\u5b9a\u6b65\u9aa4\u6309\u7167mass action\u89c4\u5f8b\uff0c\u7b2c\u4e8c\u4fe1\u4f7f\u7684\u6d53\u5ea6vs.\u54cd\u5e94\u56fe\u4e5f\u5c06\u6709\u76f8\u540c\u7684\u6807\u51c6\u5f62\u72b6\u3002\u8fd9\u4e0d\u662f\u5f88\u660e\u663e\uff0c\u4f46Black\u548cLeff\uff08\u89c1\u6fc0\u52a8\u5242\u884c\u52a8\u7684\u8fd0\u4f5c\u6a21\u5f0f\uff09\u5df2\u7ecf\u663e\u793a\u6fc0\u52a8\u5242\u6d53\u5ea6vs.\u54cd\u5e94\u56fe\u4e5f\u6709\u6807\u51c6\u5f62\u72b6\uff08\u63d0\u4f9b\u7ed1\u5b9a\u6b65\u9aa4\u6309\u7167mass action\u89c4\u5f8b\uff09\u3002\u4e8b\u5b9e\u4e0a\u5728\u5e72\u9884\u6fc0\u52a8\u5242\u7ea6\u675f\u529b\u548c\u54cd\u5e94\u4e4b\u95f4\u6709\u591a\u5c11\u6b65\u9aa4\u8fd9\u4e0d\u8981\u7d27\u3002\u53ea\u8981\u6bcf\u4e2a\u4fe1\u4f7f\u6309\u7167mass 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